5-Amino-1MQ

5‑Amino‑1MQ (5‑amino‑1‑methylquinolinium iodide). Small‑molecule NNMT inhibitor, not a peptide. Lyophilized research‑grade compound, for research use only, not for human administration.

Core Mechanism of Action

Substrate‑competitive selective inhibitor of nicotinamide N‑methyltransferase (NNMT, IC₅₀ ~1.2 μM). Blocks NNMT‑driven consumption of cellular NAD⁺ pool, elevates intracellular NAD⁺ bioavailability and activates NAD‑dependent sirtuin pathways. Reprograms adipocyte metabolism toward enhanced fatty‑acid oxidation and energy expenditure, without appetite suppression. Research topics include adipose mass regulation, insulin sensitivity, hepatic steatosis, skeletal‑muscle regenerative capacity and aging‑related metabolic signaling. No completed human clinical data available.